Avanafil

Introduction

Avanafil is designated chemically as Avanafil is an oral drug that is used for treating impotence (the inability to attain or maintain a penile erection), also known as erectile dysfunction (ED). It is in a class of drugs called phosphodiesterase inhibitors that also includes tadalafil (Cialis), sildenafil (Viagra) and vardenafil (Levitra). Erection of the penis is caused by the filling of the penis with blood. Filling occurs because the blood vessels that bring blood to the penis increase in size and deliver more blood to the penis, and, at the same time, the blood vessels that take blood away from the penis decrease in size and remove less blood from the penis. Sexual stimulation that leads to an erection causes the production and release of nitric oxide in the penis. The nitric oxide causes an enzyme, guanylate cyclase, to produce cyclic guanosine monophosphate (cGMP).

It is cGMP that is primarily responsible for increasing and decreasing the size of blood vessels carrying blood to and from the penis, respectively, and causing an erection. When the cGMP is destroyed by another enzyme, phosphodiesterase-5, the blood vessels return to their normal size, blood leaves the penis, and the erection ends. Avanafil prevents phosphodiesterase-5 from destroying cGMP so that cGMP stays around longer. The persistence of cGMP leads to a more prolonged engorgement of the penis with blood. Avanafil was approved by the FDA in April 2012.

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How it works?

The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cGMP, producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Avanafil has no direct relaxant effect on isolated human corpus cavernosum, but enhances the effect of NO by inhibiting PDE5, which is responsible for degradation of cGMP in the corpus cavernosum. Because sexual stimulation is required to initiate the local release of nitric oxide, the inhibition of PDE5 has no effect in the absence of sexual stimulation.

Side Effects

The most common side effects of avanafil are:
facial flushing (reddening),
headaches,
back pain,
nasal congestion,
dizziness, and
upper respiratory tract infections.
diarrhea,
nausea, and
flu-like symptoms

More information

Avanafil also may cause low blood pressure, blurred vision and changes in color vision, and abnormal ejaculation. Avanafil may cause prolonged erections or priapism (painful erections lasting more than 6 hours). Patients should seek immediate medical help if they experience an erection lasting more than 4 hours.

Dosages

For most individuals, the recommended starting dose of avanafil is 100 mg per day taken about 30 minutes before sexual activity. Depending on the adequacy of the response or side effects, the dose may be increased to 200 mg or decreased to 50 mg a day. Individuals who are taking medications that moderately increase the blood levels of avanafil should not exceed a total dose of 50 mg in 24 hours (See drug interactions).

Conclusion

Avanafil is a medication prescribed for the treatment of impotence (erectile dysfunction) in men. Side effects, drug interactions, warnings, and pregnancy safety information should be reviewed prior to taking this medication.

User reviews

Review 1
I’m baffled by all the negative reviews. I’ve tried Avanafil and it is by far the best: it works fast (only 15-30 minutes!), the effect lasts for 10 hours and side effects are minimal. Stendra does not improve arousal, so sexual stimulation is essential. Make sure you take it on an empty stomach and avoid any other drugs that may interact with avanafil

Review 2
Took 100mg of Avanafi. About 30 min later the wife started doing her part and the old boy was back to the glory days of firm and long. Wife was happy. No real side affects though I had a slight headache. Just an expensive option