Introduction
Zorbtive is the only drug product approved by the US Food and Drug Administration specifically for the treatment of SBS in patients receiving specialized nutritional support. Optimal management of SBS may include dietary adjustments, enteral feedings, parenteral nutrition, and fluid and micronutrient supplements, as needed. The recommended dose is 0.1 mg/kg daily up to a maximum of 8 mg per day for a treatment period of four weeks. Zorbtive™ is available in an 8.8 mg vial and is administered by subcutaneous injection.
Zorbtive is used to treat Short Bowel Syndrome (SBS) in patients who are on a specialized diet.
When used with along with special diet, Zorbtive helps your bowel take in more water, electrolytes and nutrients and lowers the need for I.V. (intravenous) feedings.
Zorbtive is not cure for Short Bowel Syndrome.
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How it works?
Zorbtive™ [somatropin (rDNA origin) for injection] is an anabolic and anticatabolic agent which exerts its influence by interacting with specific receptors on a variety of cell types including myocytes, hepatocytes, adipocytes, lymphocytes, and hematopoietic cells.
Side Effects
Headache, nausea, vomiting, fatigue, muscle pain, or weakness may occur. If these symptoms continue or become bothersome, inform your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
More information
When taking Zorbtive to treat short bowel syndrome, it is very important to follow the diet plan created for you by your doctor or nutrition counselor.
Call your doctor at once if you have sudden and severe pain in your upper stomach with nausea and vomiting, fast heartbeat, increased thirst or urination, weight loss, or vision changes and sudden, severe pain behind your eyes.
Do not stop using a steroid suddenly or change any of your medication doses without your doctor’s advice
You should not use somatropin if you have cancer, eye problems caused by diabetes. You should not use Zorbtive if you have a serious illness due to lung failure or complications from recent surgery, injury, or medical trauma.
If this medicine is used for weight loss/muscle wasting, it may take up to 2 weeks to notice the effects of the drug. Do not use more of this medication than prescribed or use it more often since the risk of side effects will be increased.
Dosages
Usual Adult Dose for Short Bowel Syndrome:
Approximately 0.1 mg/kg subcutaneously once a day
Maximum dose: 8 mg once a day
Duration of therapy: 4 weeks
Conclusion
Zorbtive™ [somatropin (rDNA origin) for injection] is a human growth hormone (hGH) produced by recombinant DNA technology. Zorbtive ™ has 191 amino acid residues and a molecular weight of 22,125 daltons. It’s amino acid sequence and structure are identical to the dominant form of human pituitary GH. Zorbtive ™ is produced by a mammalian cell line (mouse C127) that has been modified by the addition of the hGH gene. Zorbtive ™ is secreted directly through the cell membrane into the cell-culture medium for collection and purification.
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